Potential Producers of Biogenic Magnetic Nanoparticles among Pathogenic and Opportunistic Microorganisms
DOI:
https://doi.org/10.20535/ibb.2018.2.1.127260Keywords:
Magnetic field, Biogenic magnetic nanoparticles, Inflammation, Pathogenic microorganisms, Magnetic hyperthermia, Targeted deliveryAbstract
Background. The complicated forms of infection in inflammatory processes characterized by rising resistance of microorganisms to antibiotics, are forcing to find new treatments that would prevent development of pathogenic microorganisms, increased local immunity, and thus accelerated regenerative processes.
Objective. Classification of pathogenic and opportunistic microorganisms that may be potential producers of BMN, in terms of the location and properties of BMN using the methods of comparative genomics with the prospect of their subsequent use as the vectors for magnetically targeted delivery of drugs. This will make possible the use of the hyperthermia techniques for removal of pathogenic and opportunistic microorganisms that are capable of biomineralization BMN using for heating the cells directly intracellular BMN of these microorganisms.
Methods. The methods of paired and multiple sequence alignment were applied using a free access program “BLAST” of National Center for Biotechnology Information.
Results. It was revealed that strains such as E. coli (541-15), K. pneumoniae 342, C. perfringens str. 13, P. fluorescens are potential producers of crystalline magnetite and bacteria: S. aureus RF122, S. suis BM407, E. aerogenes KCTC 2190, K. pneumoniae RYC492, P. aeruginosa M18 can be producers of intracellular amorphous BMN. The power of magnetic dipole interaction between BMN of the bacteria and BMN of the tumors is in the range between 10-7–10-8 N.
Conclusions. It is explained the neutralization effect of pathogens by the method of magnetic hyperthermia due to the presence BMN, and it was proposed the use for the treatment of inflammatory processes not only antibiotic drugs, but also electromagnetic fields for those microorganisms which are producers of BMN. It is shown that as vectors for targeted delivery of drugs should be used microorganisms with natural magnetic properties, making method targeted delivery of drugs safer and more efficient, and reduced its cost.
References
Nikiforov VN. Medical applications of magnetic nanoparticles. Izvestija Akademii Inzhenernyh Nauk im. A.M. Prohorova. 2013;1:23-34.
Nikiforov VN, Brusentsov NA. Magnetic hyperthermia in oncology. Medicinskaja Fizika. 2007;2:51-9.
Banobre-Lopez M, Rodrigues D, Espina B, Azeredo J, Rivas J. Control of bacterial cells growths by magnetic hyperthermia. IEEE Trans Magn. 2013;49(7):3508-11. DOI: 10.1109/tmag.2013.2247384
Ikehara T, Park K, Yamaguchi H, Hosokawa K, Houchi H, Azuma M, et al. Effects of a time varying strong magnetic field on release of cytosolic free Ca2+ from intracellular stores in cultured bovine adrenal chromaffin cells. Bioelectromagnetics. 2002;23(7):505-15. DOI: 10.1002/bem.10043
Gorobets SV, Gorobets OYu. Function of biogenic magnetic nanoparticles in organisms. Functional Mater. 2012;19(1):18-26. DOI: 10.1002/adfm.v22.24
Gorobets SV, Gorobets OYu. Biomineralization of biogenic magnetic nanoparticles and their possible functions in cells of prokaryotes and eukaryotes. In: Dekker Encyclopedia of Nanoscience and Nanotechnology. 3rd ed. Taylor&Francis; 2014. p. 300-6.
Petrov SV. General Surgery. Saint Petersburg: Lan; 1999. 672 p.
Zilina SV, Mironov АYu, Polikarpova SV. Enterobacteriaceae in the chronic in flammatory diseases of the skin and soft tissues. Chelovek i Ego Zdorov’e. 2008;1:58-63.
Tran N, Mir A, Mallik D, Sinha A, Nayar S, Webster TJ. Bactericidal effect of iron oxide nanoparticles on Staphylococcus aureus. Int J Nanomedicine. 2010;5:277-83.
Haikarainen T, Paturi P, Lindén J, Haataja S, Meyer-Klaucke W, Finne J, et al. Magnetic properties and structural characterization of iron oxide nanoparticles formed by Streptococcus suis Dpr and four mutants. J Biol Inorganic Chem. 2011; 16(5):799-807. DOI: 10.1007/s00775-011-0781-z
Vainshtein M, Suzina N, Kudryashova E, Ariskina E. New magnet-sensitive structures in bacterial and archaeal cells. Biol Cell. 2002;94(1):29-35. DOI: 10.1016/s0248-4900(02)01179-6
Gorobets SV, Gorobets OYu, Chyzh YuМ, Demianenko IV. The genetic basis of a fundamental mechanism in the biosynthesis nanomagnetite magnitactic and an aerobic microorganisms. Visnyk Natsional'noho Chernivets'koho Universytetu. Biolohichni Systemy. 2013;5(2):274-80.
Gorobets SV, Gorobets OYu, Butenko КО, Chyzh YuМ. Biomineralization of magnet nanoparticles with bacterial symbionts of man. Medychni Perspektyvy. 2014;19(2):4-12.
Cronin M, Akin A, Collins S, Meganck J, Kim J, Baban C, et al. High resolution in vivo bioluminescent imaging for the study of bacterial tumour targeting. PLoS ONE. 2012;7(1):e30940. DOI: 10.1371/journal.pone.0030940
Sakaguchi T, Arakaki A, Matsunaga T. Desulfovibrio magneticus sp. nov., a novel sulfate-reducing bacterium that produces intracellular single-domain-sized magnetite particles. Int J System Evolution Microbiol. 2002;52(1):215-21. DOI: 10.1099/00207713-52-1-215
Bharde A, Parikh R, Baidakova M, Jouen S, Hannoyer B, Enoki T, et al. Bacteria-mediated precursor-dependent biosynthesis of superparamagnetic iron oxide and iron sulfide nanoparticles. Langmuir. 2008;24(11):5787-94. DOI: 10.1021/la704019p
Heywood B, Bazylinski D, Garratt-Reed A, Mann S, Frankel R. Controlled biosynthesis of Greigite (Fe3S4) in magnetotactic bacteria. Naturwissenschaften. 1990;77(11):536-8. DOI: 10.1007/bf01139266
Mann S, Sparks NH, Walker MM, Kirschvink JL. Ultrastructure, morphology and organization of biogenic magnetite from sockeye salmon, Oncorhynchus nerka: implications for magnetoreception. J Exp Biol. 1988;40:35.
Dobson JP, Fuller M, Moser S. Magnetic field sand iron biomineralization in the human brain. Fund Res Applications. 1995;5:16.
Schultheiss-Grassi P, Heller F, Dobson J. Analysis of magnetic material in the human heart, spleen and liver. Biometals. 1997;10:351.
Brem F, Hirt A, Winklhofer M, Frei K, Yonekawa Y, Wieser H, et al. Magnetic iron compounds in the human brain: a comparison of tumour and hippocampal tissue. J Royal Soc Interface. 2006;3(11):833-41. DOI: 10.1098/rsif.2006.0133
Chehun VF, Gorobets SV, Gorobets OYu, Demianenko IV. Magnetic nanostructures in tumor cells application of scanning probemicroscopy to study the structural organization magnetosensitive phase in tumor cells. Visnyk NAN Ukrayiny. 2011;11:13-20.
Alexeeva TA, Gorobets SV, Gorobets OYu, Demianenko IV, Lazarenko OM. Magnetic force microscopy atherosclerotic plaques. Medychni Perspektyvy. 2014;19(1):4-10.
Dobson J. Nanoscale biogenic iron oxides and neurodegenerative disease. FEBS Letters. 2001;496(1):1-5. DOI: 10.1016/s0014-5793(01)02386-9
Gorobets OYu, Gorobets SV, Sorokina LV. Biomineralization and syntesis of biogenic magnetic nanoparticles and magnetosensitive inclusions in microorganisms and fungi. Functional Mater. 2014;4:15-21.
Gorobets SV, Gorobets OIu, Chizh IuM, Siveniuk DV. Magnetic dipole interaction of endogenous magnetic nanoparticles with magnetic liposomes in the targeted drug delivery. Biofizika. 2013;58(3):488-94.
BLAST: Basic local alignment search tool [Internet].
Blast.ncbi.nlm.nih.gov. Available from: http://blast.ncbi.nlm.nih.gov
Patyar S, Joshi R, Byrav D, Prakash A, Medhi B, Das B. Bacteria in cancer therapy: a novel experimental strategy. J Biomed Sci. 2010;17(1):21. DOI: 10.1186/1423-0127-17-21
Kitagawa M, Koh T, Nakagawa N, Kondo Y, Nishio M, Oguro A, et al. Gastrointestinal stromal tumor in a patient with neurofibromatosis: Abscess formation in the tumor leading to bacteremia and seizure. Case Rep Gastroenterol. 2010;4(3):435-42. DOI: 10.1159/000321523
Wei M, Ellem K, Dunn P, West M, Bai C, Vogelstein B. Facultative or obligate anaerobic bacteria have the potential for multimodality therapy of solid tumours. Eur J Cancer. 2007;43(3):490-6. DOI: 10.1016/j.ejca.2006.10.005
Berzofsky J, Berkover А. Antigen-antibody interaction. In: Paul W, Ed. Immunology. Moscow: Mir; 1989. p. 87.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2018 Igor Sikorsky Kyiv Polytechnic Institute
This work is licensed under a Creative Commons Attribution 4.0 International License.
The ownership of copyright remains with the Authors.
Authors may use their own material in other publications provided that the Journal is acknowledged as the original place of publication and National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute” as the Publisher.
Authors are reminded that it is their responsibility to comply with copyright laws. It is essential to ensure that no part of the text or illustrations have appeared or are due to appear in other publications, without prior permission from the copyright holder.
IBB articles are published under Creative Commons licence:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under CC BY 4.0 that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
