The Characteristic of the Gastric Secretion After Gastric Cryodenervation and Cryopreserved Placenta Extract Administration

Authors

DOI:

https://doi.org/10.20535/ibb.2023.7.1.280183

Keywords:

gastric secretion, gastric juice acidity, trunk gastric cryodenervation, cryopreservation

Abstract

Background. Peptic ulcer is a prevalent gastrointestinal tract disease worldwide. One of the treatment methods for the indicated pathology is trunk gastric cryodenervation (TGC), the feature of which is the preservation of the regenerative potential of n. vagus. Cryopreserved placenta extract (CPE) caught our attention among modern means capable of stimulating regeneration processes.

Objective. We are aimed to characterize the state of gastric secretion after TGC and the application of СPE.

Methods. TGC was performed by cryoinfusion on the front and back trunks of the abdominal part of n. vagus. Gastric secretion was studied using the H.A. Shay method.

Results. On the 30th day after TGC, a statistically significant (p < 0.001) decrease in the total acidity of gastric juice by 33.7% and
a decrease (p < 0.01) in the level of free acidity were observed compared to intact animals. Administration of СPE after TGC resulted in
a statistically significant (p < 0.001) decrease in total acidity by 24.2 % and a statistically significant (p < 0.001) decrease in free acidity by 48.7% compared to the parameters of intact rats. This led to a statistically significant (p < 0.001) decrease in the "free/bound acidity" ratio compared to the indicator of intact animals (1.4 ± 0.03 RU) which was higher than the similar ratio observed after esomeprazole usage or TGC.

Conclusions. Administration of СPE contributed to the partial regeneration of n. vagus, as indicated by an increase in the level of total acidity to 104.1 ± 4.7 RU and a statistically significant (p < 0.001) decrease in the "free/bound acidity" ratio compared to the indicator of intact animals.

References

Sabadishin RO. Gastric ulcer: etiological and pathogenetic causes. Med Ukr. 2021;7(253):24-7. DOI: 10.37987/1997-9894.2021.7(253).245652

Bereda G. Peptic ulcer disease: Definition, pathophysiology, and treatment. J Biomed Bio Sci. 2021;1(2):1-10.

Shell EJ. Pathophysiology of peptic ulcer disease. Physician Assistant Clinics. 2021;6(4):603-11. DOI: 10.1016/j.cpha.2021.05.005

Dunlap JJ, Patterson S. Peptic ulcer disease. Gastroenterol Nurs. 2019;42(5):451-4. DOI: 10.1097/SGA.0000000000000478

Fatovic-Ferencic S, Banic M. No acid, no ulcer: Dragutin (Carl) Schwarz (1868-1917), the man ahead of his time. Dig Dis. 2011;29(5):507-10. DOI: 10.1159/000334384

Lagoo J, Pappas TN, Perez A. A relic or still relevant: the narrowing role for vagotomy in the treatment of peptic ulcer disease. Am J Surg. 2014;207(1):120-6. DOI: 10.1016/j.amjsurg.2013.02.012

Turnage RH, Sarosi G, Cryer B, Spechler S, Peterson W, Feldman M. Evaluation and management of patients with recurrent peptic ulcer disease after acid-reducing operations: a systematic review. J Gastrointest Surg. 2003;7(5):606-26. DOI: 10.1016/s1091-255x(02)00034-3

Palanivelu C, Jani K, Rajan PS, Kumar KS, Madhankumar MV, Kavalakat A. Laparoscopic management of acid peptic disease. Surg Laparosc Endosc Percutan Tech. 2006;16(5):312-6. DOI: 10.1097/01.sle.0000213742.70030.96

Hurtado-Andrade H. Surgical treatment of peptic ulcer. Rev Gastroenterol Mex. 2003;68(2):143-55.

Brimblecombe RW, Duncan WA, Durant GJ, Ganellin CR, Parsons ME, Black JW. The pharmacology of cimetidine, a new histamine H2-receptor antagonist. Br J Pharmacol. 1975;53(3):435-6.

Jani K, Saxena A, Kothari A. Laparoscopic truncal vagotomy with gastrojejunostomy. J Indian Med Assoc. 2010;108(10):648-51.

Abdel-Salam WN, Katri KM, Bessa SS, El-Kayal el-SA. Laparoscopic-assisted truncal vagotomy and gastro-jejunostomy: trial of simplification. J Laparoendosc Adv Surg Tech. A. 2009 Apr;19(2):125-7. DOI: 10.1089/lap.2008.0250

Wu SC, Cheng HT, Wang YC, Tzeng CW, Hsu CH, Muo CH. Decreased risk of liver and intrahepatic cancer in non-H. pylori-infected perforated peptic ulcer patients with truncal vagotomy: a nationwide study. Sci Rep. 2021;11(1):15594. DOI: 10.1038/s41598-021-95142-z

Lavigne ME, Wiley ZD, Martin P, Way LW, Meyer JH, Sleisenger MH, et al. Gastric, pancreatic, and biliary secretion and the rate of gastric emptying after parietal cell vagotomy. Am J Surg. 1979;138(5):644-51. DOI: 10.1016/0002-9610(79)90337-4

Boulos PB, Faber RG, Whitfield PF, Parkin JV, Hobsley M. Relationship between insulin- and histamine-stimulated gastric secretion before and after vagotomy. Gut. 1983;24(6):549-56. DOI: 10.1136/gut.24.6.549

Koo J, Lam SK, Boey J, Lee NW. Gastric acid secretion and its predictive value after vagotomy for perforated duodenal ulcer. Scand J Gastroenterol. 1983;18(7):929-34. DOI: 10.3109/00365528309182117

Lundegårdh G, Ekbom A, McLaughlin JK, Nyrén O. Gastric cancer risk after vagotomy. Gut. 1994;35(7):946-9. DOI: 10.1136/gut.35.7.946

Cohen F, Valleur P, Serra J, Brisset D, Chiche L, Hautefeuille P. Relationship between gastric acid secretion and the rate of recurrent ulcer after parietal cell vagotomy. Ann Surg. 1993;217(3):253-9. DOI: 10.1097/00000658-199303000-00007

Aumpan N, Mahachai V, Vilaichone RK. Management of Helicobacter pylori infection. JGH Open. 2022;7(1):3-15. DOI: 10.1002/jgh3.12843

Chyzh MO, Belochkina IV, Hladkykh FV. Cryosurgery and physical medicine in treatment of cancer. Ukr J Radiol Oncol. 2021;29(2):127-49. DOI: 10.46879/ukroj.2.2021.127–149

Hladkykh FV. Characteristic of mechanisms of antiulcerogenic action of agents of vanilloid receptors (TRPV1) on the model of gastropathy induced by acetylsalicylic acid. Pharm Pharmacol. 2017;5(3):283-301. DOI: 10.19163/2307-9266-2017-5-3-283-301

Pan SY, Chan MKS, Wong MBF, Klokol D, Chernykh V. Placental therapy: An insight to their biological and therapeutic properties. J Med Ther. 2017;1(3):1-6. DOI: 10.15761/JMT.1000118

Koshurba IV, Chyzh MO, Hladkykh FV, Belochkina IV. Influence of placenta cryoextract on the liver metabolic and functional state in case of D-galactosamine hepatitis. Innov Biosyst Bioeng. 2022;6(2):64-7. DOI: 10.20535/ibb.2022.6.2.264774

Tarnawski AS, Ahluwalia A. The critical role of growth factors in gastric ulcer healing: the cellular and molecular mechanisms and potential clinical implications. Cells. 2021;10(8):1964. DOI: 10.3390/cells10081964

Hladkykh FV. Experimental study of the antiulcer effect of cryopreserved placenta extract on a model of acetylsalicylic acid-induced ulcerogenesis. Curr Issues Pharm Med Sci. 2022;35(2):89-94. DOI: 10.2478/cipms-2022-0017

Koshurba IV, Hladkykh FV, Chyzh MO. Comparative characteristics of antiulcer activity of placental cryoextract under different modes of application in the experiment. Actual Probl Modern Med Bull Ukr Med Stomatolog Acad. 2022;22(2):65-70. DOI: 10.31718/2077-1096.22.2.65

Hladkykh FV, Koshurba IV, Chyzh MO. Characteristics of the antiulcerogenic activity of cryopreserved placenta extract in acute and chronic lesions of the stomach. Modern Med Technol. 2023;1:62-8. DOI: 10.34287/MMT.1(56).2023.10

Hladkykh FV. The effect of meloxicam and cryopreserved placenta extract on initial inflammatory response (an experimental study). Ceska Slovenska Farmacie. 2021;70(5):179-85. DOI: 10.5817/CSF2021-5-179

Koshurba IV, Hladkykh FV, Chyzh MO, Belochkina IV, Rubleva TV. Hepatotropic effects of triple antiulcer therapy and placenta cryoextract: the role of sex factors in lipoperoxidation. Fiziol Zh. 2022;68(5):25-32. DOI: 10.15407/fz68.05.025

Chyzh MO, Koshurba IV, Marchenko MM, Hladkykh FV, Belochkina IV. Gender determinism of the effect of placenta cryoextract on the hepatotropic effects of esomeprazole, clarithromycin and metronidazole in chronic liver damage. Modern Med Technol. 2023;1:55-61. DOI: 10.34287/MMT.1(56).2023.9

Hladkykh FV. Anti-inflammatory properties of diclofenac sodium on the background of combined use with cryopreserved placenta extract in the experiment. Probl Cryobiol Cryomed 2021;31(4):364-7. DOI: 10.15407/cryo31.04.364

Vogel HG, editor. Drug discovery and evaluation: Pharmacological assays. Berlin, Heidelberg: Springer; 2008. 2071 p. DOI: 10.1007/978-3-540-70995-4

Chyzh M, Belozorov I, Aschabov D, Komyshanchenko D, Globa V, Marchenko L, et al. Cryosurgical method for nervus vagus ablation in experimental studies. Probl Cryobiol Cryomed. 2020;30(1):90-8. DOI: 10.15407/cryo30.01.090

Simons CT, Kulchitsky VA, Sugimoto N, Homer LD, Székely M, Romanovsky AA. Signaling the brain in systemic inflammation: which vagal branch is involved in fever genesis? Am J Physiol. 1998;275(1):63-8. DOI: 10.1152/ajpregu.1998.275.1.R63

Hladkykh F, Chyzh M. Modulation of meloxicam-induced changes in gastrointestinal and motor activity of the stomach by applying placenta cryoextract. Proc Shevchenko Sci Soc Med Sci. 2021;64(1):84-94. DOI: 10.25040/ntsh2021.01.08

Hladkykh FV. Gastrocytoprotective properties of cryopreserved placenta extract in combined action of low temperatures and inhibition of cyclooxygenase. Acta Facultatis Medicae Naissensis. 2022;39(1):48-56. DOI: 10.5937/afmnai39-33036

Shay H, Komarov S, Fels SS, Meranze D, Gruenshtein M, Siplet H. A simple method for the uniform production of gastric ulceration in the rat. Gastroenterology. 1945;5:43-61.

Zar JH. Biostatistical analysis. 5 ed. Englewood: Prentice-Hall; 2014. 960 р.

Tolbert MK. Gastroprotective THERAPY. Vet Clin North Am Small Anim Pract. 2021 Jan;51(1):33-41. DOI: 10.1016/j.cvsm.2020.09.001

Koyyada A. Long-term use of proton pump inhibitors as a risk factor for various adverse manifestations. Therapie. 2021;76(1):13-21. DOI: 10.1016/j.therap.2020.06.019

Garg V, Narang P, Taneja R. Antacids revisited: review on contemporary facts and relevance for self-management. J Int Med Res. 2022;50(3):3000605221086457. DOI: 10.1177/03000605221086457

Iwagami M, Kumazawa R, Miyamoto Y, Ito Y, Ishimaru M, Morita K, et al. Risk of cancer in association with ranitidine and nizatidine vs other H2 blockers: Analysis of the Japan Medical Data Center Claims Database 2005-2018. Drug Saf. 2021;44(3):361-71. DOI: 10.1007/s40264-020-01024-0

Lespessailles E, Toumi H. Proton pump inhibitors and bone health: An update narrative review. Int J Mol Sci. 2022;23(18):10733. DOI: 10.3390/ijms231810733

Hladkykh FV, Chyzh MO. Nonsteroidal anti-inflammatory drugs: a modern understanding of the mechanisms of damage to the digestive tract, the shortcomings of pathogenetic drugs and prospects for biological therapy of NSAID-induced esophagogastroenterocolonopathy. Gastroenterology. 2020;54(4):253-66. DOI: 10.22141/2308-2097.54.4.2020.216714

Xu Y, Tian X, Wang W, Tian W, Zhang T, Sun J, et al. Pharmacokinetics of esomeprazole in critically ill patients. Front Med (Lausanne). 2022;8:621406. DOI: 10.3389/fmed.2021.621406

Rao SSC, Bhagatwala J. Small intestinal bacterial overgrowth: Clinical features and therapeutic management. Clin Transl Gastroenterol. 2019;10(10):e00078. DOI: 10.14309/ctg.0000000000000078

Ward EK, Schuster DP, Stowers KH, Royse AK, Ir D, Robertson CE, et al. The effect of PPI use on human gut microbiota and weight loss in patients undergoing laparoscopic Roux-en-Y gastric bypass. Obes Surg. 2014;24(9):1567-71. DOI: 10.1007/s11695-014-1275-1

Strand DS, Kim D, Peura DA. 25 years of proton pump inhibitors: A comprehensive review. Gut Liver. 2017;11(1):27-37. DOI: 10.5009/gnl15502

Ilfeld BM, Preciado J, Trescot AM. Novel cryoneurolysis device for the treatment of sensory and motor peripheral nerves. Expert Rev Med Devices. 2016;13(8):713-25. DOI: 10.1080/17434440.2016.1204229

Andrade JG, Dubuc M, Ferreira J, Guerra PG, Landry E, Coulombe N, et al. Histopathology of cryoballoon ablation-induced phrenic nerve injury. J Cardiovasc Electrophysiol. 2014;25(2):187-94. DOI: 10.1111/jce.12296

Gula LJ. Phrenic nerve damage from cryoablation: dealbreaker or just a hiccup? J Cardiovasc Electrophysiol. 2014;25(2):195-6. DOI: 10.1111/jce.12299

Tarnawski AS, Ahluwalia A. The critical role of growth factors in gastric ulcer healing: The cellular and molecular mechanisms and potential clinical implications. Cells. 2021;10(8):1964. DOI: 10.3390/cells10081964

Onger ME, Delibaş B, Türkmen AP, Erener E, Altunkaynak BZ, Kaplan S. The role of growth factors in nerve regeneration. Drug Discov Ther. 2017;10(6):285-91. DOI: 10.5582/ddt.2016.01058

Published

2023-06-01

How to Cite

1.
Koshurba I, Hladkykh F, Chyzh M, Marchenko M, Belochkina I. The Characteristic of the Gastric Secretion After Gastric Cryodenervation and Cryopreserved Placenta Extract Administration. Innov Biosyst Bioeng [Internet]. 2023Jun.1 [cited 2024Mar.28];7(1):42-51. Available from: http://ibb.kpi.ua/article/view/280183

Issue

Section

Articles