Experience in Clinical Application of Cryopreserved Placental Derivatives: Cells, Tissue, Membranes, Extract, and Cord Blood Serum
DOI:
https://doi.org/10.20535/ibb.2020.4.3.215215Keywords:
Cell therapy, Tissue therapy, Placenta, Biobanking, Regenerative medicine, Stem cellsAbstract
Background. The human placenta is a promising source of biomaterial for regenerative medicine. This is primarily due to the availability of a sufficient amount of material, low immunogenicity, a large number of stem cells, and high proliferative cell potential. The effectiveness of stem cells, their lysates, and conditioned media in various pathological conditions has been proven in many studies. Most studies are experimental, or are in different phases of clinical trials. At the same time, in Ukraine there is a wealth of experience of clinical using the cryopreserved placenta medico-immunobiological preparations, which can be the basis for further application of placental material.
Objective. We aim to perform a critical analysis of data on the effectiveness and prospects of application of the cryopreserved placenta preparations (cells, tissues, membranes, extract and cord blood serum) in clinical practice.
Methods. The results of clinical application of 2,579 medical immunobiological Platex and Cryocell placenta preparations were analyzed. An attention was paid to the effectiveness, course of concomitant, comorbid pathology in patients, as well as the presence of negative responses and complications. The number of the preparations used and the one of the patients according to the nosological forms were counted.
Results. The experience of application of medical immunobiological preparations of placental origin in obstetric-gynecological, therapeutic, neurological and endocrinological pathologies is analyzed in the work. The obtained data are compared with the research results in the corresponding model experiments of in vitro and in vivo systems. The positive effect of placental preparations on the course of miscarriage, climacteric syndrome, infertility, diabetes mellitus, coronary heart disease, multiple sclerosis, amyotrophic lateral sclerosis, trophic ulcers has been determined. Contraindications for placenta preparations are some malignancies and an infectious disease process without proper pathogen elimination.
Conclusions. Cryopreserved placenta preparations are effective when used in obstetric, gynecological, neurological, endocrinological and therapeutic practice. Their effect is primarily observed in diseases, which are accompanied by autoimmune reactions, hormonal disorders, dysplastic or degenerative processes. The restricted application of placenta preparations is infectious disease process without proper pathogen elimination.References
Brown C, McKee C, Bakshi S, Walker K, Hakman E, Halassy S, et al. Mesenchymal stem cells: cell therapy and regeneration potential. J Tissue Eng Regen Med. 2019 Sep;13(9):1738-55. DOI: 10.1002/term.2914
Pogozhykh O, Prokopyuk V, Figueiredo C, Pogozhykh D. Placenta and placental derivatives in regenerative therapies: experimental studies, history, and prospects. Stem Cells Int. 2018 Jan;2018:4837930. DOI: 10.1155/2018/4837930
Silini AR, Cargnoni A, Magatti M, Pianta S, Parolini O. The long path of human placenta, and its derivatives, in regenerative medicine. Front Bioeng Biotechnol. 2015 Oct;3(162):1. DOI: 10.3389/fbioe.2015.00162
Moon PD, Kim KY, Rew KH, Kim HM, Jeong HJ. Anti-fatigue effects of porcine placenta and its amino acids in a behavioral test on mice. Can J Physiol Pharmacol. 2014 Sep;92(11):937-44. DOI: 10.1139/cjpp-2014-0068
Perillo A, Bonanno G, Pierelli L, Rutella S, Scambia G, Mancuso S. Stem cells in gynecology and obstetrics. Panminerva Med. 2004 Mar;46(1):49-59.
Pipino C, Shangaris P, Resca E, Zia S, Deprest J, Sebire NJ, et al. Placenta as a reservoir of stem cells: an underutilized resource? Br Med Bull. 2012 Nov;105(1):43-68. DOI: 10.1093/bmb/lds033
Prokopyuk VYu, Grischenko OV, Prokopyuk OV, Shevchenko NO, Falko OV, Storchak AV, et al. Effect of cryopreserved placental explants on female reproductive system under normal and pathological conditions (experimental study). Probl Cryobiol Cryomed. 2017 Sep;28(3):250-65. DOI: 10.15407/cryo27.03.250
Grishchenko VI, Yurchenko TN, editors. Placenta: Cryopreservation, structure, properties, prospects for clinical application. Kharkiv: Borovin Publ.; 2011. 268 p.
Goltsev AN, editor. Actual problems of cryobiology and cryomedicine. Kharkiv: Raider; 2012. p. 469-86.
Kozub MM, Prokopyuk VYu, Skibina KP, Prokopyuk OV, Kozub NI. Comparison of various of tissue and cell therapy approaches when restoring ovarian, hepatic and kidney's function after chemotherapy-induced ovarian failure. Exp Oncol. 2017 Sep;39(3):181-5. DOI: 10.31768/2312-8852.2017.39(3):181-185
Prokopiuk VY. Influence of media conditioned by cryopreserved and fresh placental explants and cells on murine uterine and ovarian organotypic cultures. Probl Cryobiol Cryomed. 2018 Mar;28(2):139-50. DOI: 10.15407/cryo28.02.139
Prokopyuk OS, Prokopyuk VY, Pasieshvili NM, Chyzhevskiy VV, Trifonov VY, Karpenko VG, et al. Implantation of cryopreserved human placental fragments restores prooxidant-antioxidant balance in experimental animals of late ontogeny. Cryobiol Cryomed. 2017;27(1):61-70. DOI: 10.15407/cryo27.01.061
Pischiutta F, Sammali E, Parolini O, Carswell HVO, Zanier ER. Placenta-derived cells for acute brain injury. Cell Transplant. 2018 Jan;27(1):151-67. DOI: 10.1177/0963689717732992
Prokopyuk VY, Chub OV, Shevchenko MV, Prokopyuk OS. Placental stem cells, organotypic culture and human placenta extract have neuroprotective activity. Cell Organ Transplant. 2017 May;5(1):39-42. DOI: 10.22494/cot.v5i1.67
Ringden O, Baygan A, Remberger M, Gustafsson B, Winiarski J, Khoein B, et al. Placenta-derived decidua stromal cells for treatment of severe acute graft-versus-host disease. Stem Cells Transl Med. 2018 Apr;7(4):325-31. DOI: 10.1002/sctm.17-0167
Seo TB, Han IS, Yoon JH. Growth-promoting activity of Hominis Placenta extract on regenerating sciatic nerve. Acta Pharmacol Sin. 2006 Jan;27(1):50-8. DOI: 10.1111/j.1745-7254.2006.00252.x
Musatova IB, Volina VV, Chub OV, Prokopyuk VY, Prokopyuk OS. Effects of implantation of cryopreserved placental explants on the behavioral indices and morphological characteristics of the cerebral structures in senescent mice. Neurophysiology. 2017 Oct;49(5):363-71. DOI: 10.1007/s11062-018-9696-4
Jirsova K, Jones GLA. Amniotic membrane in ophthalmology: properties, preparation, storage and indications for grafting – a review. Cell Tissue Bank. 2017 Jun;18(2):193-204. DOI: 10.1007/s10561-017-9618-5
Paolin A, Cogliati E, Trojan D, Griffoni C, Grassetto A, Elbadawy HM, et al. Amniotic membranes in ophthalmology: long term data on transplantation outcomes. Cell Tissue Bank. 2016 Mar;17(1):51-8. DOI: 10.1007/s10561-015-9520-y
Samadi P, Saki S, Khoshinani HM, Sheykhhasan M. Therapeutic applications of mesenchymal stem cells: a comprehensive review. Curr Stem Cell Res Ther. 2020 Sep 14;15(1):1. DOI: 10.2174/1574888X15666200914142709
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