Attenuation of Paraquat-Induced Nephrotoxicity and Dysfunction in Male Wistar Albino Rats


  • Cosmas O. Ujowundu Federal University of Technology, Nigeria
  • Peter-Oscar I. Anaba Federal University of Technology, Nigeria
  • Ngozi B. Ulinasombu Federal University of Technology, Nigeria
  • Favour N. Ujowundu Federal University of Technology, Nigeria
  • Kalu O. Igwe Federal University of Technology, Nigeria
  • Henry D. Ogbuagu Federal University of Technology, Nigeria



Paraquat, Herbicide, Nephrotoxicity, Xenobiotics, Antioxidants


Background. Paraquat (PQ) is a pesticide commonly used in the control of weed in agricultural practices worldwide. Exposure to PQ has adverse biochemical and physiological consequences to humans and animals. The mechanism of toxicity is linked to the generation of reactive oxygen species and subsequent lipid peroxidation. Presently, no single effective antidote to PQ toxicity has been established. Therefore, the need to continually investigate different treatment approaches is of paramount importance.

Objective. This study evaluated the capacity of selected dietary supplements to attenuate paraquat-induced kidney dysfunction and damages by determining some kidney function biomarkers and oxidative parameters.

Methods. Thirty-six Wistar albino rats were randomly separated into six groups. Each group (except Normal control) was intoxicated every other day with 1.5 mg/kg body weight of PQ and four groups (except PQ and Normal control groups) were treated daily with 40 mg/kg of garlic, glutathione and vitamin C for two weeks.

Results. The results showed significant (p < 0.05) increases in concentration of kidney malondialdehyde, urea, creatinine, and blood lipid profiles. Also, significant decrease in concentrations of high-density lipoprotein cholesterol, kidney glutathione and total antioxidant capacity were presented by PQ control group compared to other PQ exposed groups treated with the antioxidant compounds.

Conclusions. PQ-induced changes indicated kidney dysfunction and damage. However, the administration of antioxidant supplements attenuated the PQ-induced biochemical and physiological dysfunction in the rats.

Author Biographies

Cosmas O. Ujowundu, Federal University of Technology

Department of Biochemistry

Peter-Oscar I. Anaba, Federal University of Technology

Department of Biochemistry

Ngozi B. Ulinasombu, Federal University of Technology

Department of Biochemistry

Favour N. Ujowundu, Federal University of Technology

Department of Biochemistry

Kalu O. Igwe, Federal University of Technology

Department of Biochemistry

Henry D. Ogbuagu, Federal University of Technology

Department of Biology


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How to Cite

Ujowundu CO, Anaba P-OI, Ulinasombu NB, Ujowundu FN, Igwe KO, Ogbuagu HD. Attenuation of Paraquat-Induced Nephrotoxicity and Dysfunction in Male Wistar Albino Rats. Innov Biosyst Bioeng [Internet]. 2020Mar.3 [cited 2024Jun.23];4(1):26-35. Available from: