Investigation of Safety and Efficacy of Antipediculosis Products on the Basis of Essential Oils
Background. Despite the fact that the problem of pediculosis in children and adults exists for a long time, it does not lose its relevance. The relevance of the pediculosis is due to the fact that everyone can easily get infected with this disease, but infants are infected more often. Pediculosis is an indicator of social disadvantage, it is a socio-psychological problem for the patients and those around them, and can also create epidemic disadvantages in society since these lice can be of pathogen carriers of dangerous diseases. Therefore, the development of means for prevention and control of lousiness, in particular, the development of new pediculicids based on natural essential oils, is a further urgent task.
Objective. The aim of the paper is to study and prove the insecticidal (pediculicidal) and ovicidal activity of hair lotions made on the basis of lavender and ylang-ylang natural essential oils in laboratory conditions and to assess the safety of lotions when used in infected patients.
Methods. The method of biological quality control has been used to the study of hair lotions made on the basis of lavender and ylang-ylang natural essential oils to determine their biological activity against the lice of the Pediculus humanus humanus laboratory population on the laboratory base of rickettsia infections of the Lviv Research Institute of Epidemiology and Hygiene of the Ministry of Health of Ukraine. The study of the safety of lotions was carried out with the involvement of healthy volunteers and patients with pediculosis on theKiev city disinfection station base (department of chamber disinfection and sanitary passersby).
Results. The model formula for lotion made using 3.5 % lavender oil and 3.5 % ylang-ylang oil, causes 100 % death of the lice imago during exposure for 30 minutes. At less exposure, the lice imago death is reduced. Ovicidal properties are expressed during exposure for 30 min. The product is safe for humans, well tolerated and provides effective death of the lice, regardless of the patient infesting degree.Conclusions. The results of the study of the model formulations of lotions indicate their high insecticidal and ovicidal activity in relation to the lice of the laboratory population when immersing test-insects in one of the studied lotions and adding the test-insects to the filter paper, moistened with one of the indicated lotions, with an exposure of 30 min. The product does not require additional safety measures and may be used in accordance with the directions for use.
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